Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells
Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells
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DOI：
10.1159/000080663
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发表时间：
2004-01-01
影响因子：
4.1
通讯作者：
Asou, H
中科院分区：
文献类型：
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作者：
Seiwa, C;Nakahara, J;Asou, H
我们报道了双酚A （BPA）对少突胶质前体细胞（OPCs）分化的作用机制。结果表明：(1)BPA可抑制甲状腺激素（T-3）诱导的OPCs分化。(2)该效应通过甲状腺激素受体（TRbeta1）介导，该受体被认为负责OPC分化。(3) BPA对OPC分化的作用不涉及作为OPC分化诱导剂的fgamma - fn -髓鞘碱性蛋白（MBP）级联，也不抑制被认为是由T-3-TR复合物诱导的CREB磷酸化。(4)在OPCs中检测到MBP异构体（21.5,18.5,17.0和14.0 kDa）的存在，T-3处理后含有外显子2的异构体（17.0和21.5 kDa）的表达上调。相反，BPA抑制MBP的表达。版权所有(C) 2004 S. Karger AG，巴塞尔。
We report studies on the mechanism of action of bisphenol A (BPA) on the differentiation of oligodendrocyte precursor cells (OPCs). Our results show that: ( 1) BPA inhibits the differentiation of OPCs induced by exposure to thyroid hormone (T-3). ( 2) The effect is mediated through various mechanisms via the thyroid hormone receptor (TRbeta1) which is considered to be responsible for OPC differentiation. ( 3) The action of BPA on OPC differentiation does not involve the FcRgamma-Fyn-myelin basic protein (MBP) cascade as an inducer of OPC differentiation nor does it suppress CREB phosphorylation, which is considered to be induced by the T-3-TR complex. (4) The presence of MBP isoforms (21.5, 18.5, 17.0 and 14.0 kDa) was detected in OPCs, and the expression of exon 2-containing isoforms (i.e. 17.0 and 21.5 kDa) was upregulated upon treatment with T-3. In contrast, expression of MBP was inhibited by BPA. Copyright (C) 2004 S. Karger AG, Basel.