Testicular aging, male fertility and beyond.
Testicular aging, male fertility and beyond.
复制标题
睾丸衰老、男性生育能力等
DOI：
10.3389/fendo.2022.1012119
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发表时间：
2022
影响因子：
5.2
通讯作者：
Zhang, Xiaoning
中科院分区：
文献类型：
--
作者：
Dong, Shijue;Chen, Chen;Zhang, Jiali;Gao, Yuan;Zeng, Xuhui;Zhang, Xiaoning
Normal spermatogenesis and sperm function are crucial for male fertility. The effects of healthy testicular aging and testicular premature aging on spermatogenesis, sperm function, and the spermatogenesis microenvironment cannot be ignored. Compared with younger men, the testis of older men tends to have disturbed spermatogenic processes, sperm abnormalities, sperm dysfunction, and impaired Sertoli and Leydig cells, which ultimately results in male infertility. Various exogenous and endogenous factors also contribute to pathological testicular premature aging, such as adverse environmental stressors and gene mutations. Mechanistically, Y-chromosomal microdeletions, increase in telomere length and oxidative stress, accumulation of DNA damage with decreased repair ability, alterations in epigenetic modifications, miRNA and lncRNA expression abnormalities, have been associated with impaired male fertility due to aging. In recent years, the key molecules and signaling pathways that regulate testicular aging and premature aging have been identified, thereby providing new strategies for diagnosis and treatment. This review provides a comprehensive overview of the underlying mechanisms of aging on spermatogenesis. Furthermore, potential rescue measures for reproductive aging have been discussed. Finally, the inadequacy of testicular aging research and future directions for research have been envisaged to aid in the diagnosis and treatment of testicular aging and premature aging.
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影响因子：
3.7
作者：
Crary-Dooley FK;Tam ME;Dunaway KW;Hertz-Picciotto I;Schmidt RJ;LaSalle JM
通讯作者：
LaSalle JM
DOI：
10.1096/fj.201800612r
发表时间：
2019-01
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Curley M;Milne L;Smith S;Jørgensen A;Frederiksen H;Hadoke P;Potter P;Smith LB
通讯作者：
Smith LB
影响因子：
3.1
作者：
Bartolacci, Alessandro;Pagliardini, Luca;Vigano, Paola
通讯作者：
Vigano, Paola
影响因子：
2.2
作者：
Alshinnawy, Ameera S.;El-Sayed, Wael M.;Salem, Ahmed M.
通讯作者：
Salem, Ahmed M.
DOI：
10.1007/bf03340164
发表时间：
1998-12-01
期刊：
AGING-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Barnes, CJ;Covington, BW;Lee, M
通讯作者：
Lee, M