The effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid media.
The effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid media.
复制标题
抗真菌药物联合使用对固体和液体培养基中光滑念珠菌生长的影响。
DOI：
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发表时间：
1998
影响因子：
5.2
通讯作者：
D. Kerridge
中科院分区：
文献类型：
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作者：
H. Siau;D. Kerridge
在固体培养基中通过证明减少或增强生长，以及在液体培养基中通过测定相互作用指数，研究了药物组合对光滑念珠菌生长的影响。两性霉素B和5-氟胞嘧啶表现出协同作用，而两性霉素B和咪康唑以及咪康唑和5-氟胞嘧啶的组合表现出拮抗作用。此外，在代谢抑制剂组合中，在甾醇生物合成抑制剂（特比萘芬、咪康唑、酮康唑、克霉唑、益康唑、氟康唑、伊曲康唑和阿莫罗芬）与核酸或蛋白质生物合成抑制剂（5-氟胞嘧啶、5-氟尿嘧啶、利福平和金霉素）之间观察到浓度依赖性拮抗作用。这种拮抗作用是菌株特异性的，发生在C。glabrata 4株、酿酒酵母237株和白色念珠菌72 R株的抗真菌能力较强，但与C.白色念珠菌菌株6406或近平滑念珠菌菌株3104。
The effect of drugs in combination on the growth of Candida glabrata was studied in solid medium by demonstration of reduced or enhanced growth, and in liquid medium by determination of interaction indices. Amphotericin B and 5-fluorocytosine showed a synergic effect, while combinations of amphotericin B and miconazole, and miconazole and 5-fluorocytosine exhibited antagonistic effects. In addition, concentration-dependent antagonism was observed amongst combinations of metabolic inhibitors, between inhibitors of sterol biosynthesis (terbinafine, miconazole, ketoconazole, clotrimazole, econazole, fluconazole, itraconazole and amorolfine) and inhibitors of nucleic acid or protein biosynthesis (5-fluorocytosine, 5-fluorouracil, rifampicin and chlortetracycline). This antagonism was strain-specific, occurring with C. glabrata strain 4, Saccharomyces cerevisiae strain 237 and Candida albicans strain 72R, but not with C. albicans strain 6406 or Candida parapsilosis strain 3104.
两性霉素 B 与其他多烯或咪唑抗生素联合使用具有抗真菌作用。
DOI：
10.1093/infdis/146.2.138
发表时间：
1982
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brajtburg,J;Kobayashi,D;Medoff,G;Kobayashi,GS
通讯作者：
Kobayashi,GS