An improved synthesis of piperlongumine and the preliminary imaging evaluation on tumor targeting
An improved synthesis of piperlongumine and the preliminary imaging evaluation on tumor targeting
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胡椒长明的合成改进及肿瘤靶向影像学初步评价
DOI：
10.1007/s10967-020-07117-5
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发表时间：
2020-03
影响因子：
1.6
通讯作者：
Chuan Zhang
中科院分区：
文献类型：
--
作者：
Kun He;Honglei Xu;Tingfang Wang;Xiao Li;Bingjie Guo;Danni Li;Yi Li;Chuan Zhang
Piperlongumine is a natural product that exhibited anti-cancer effect for various tumor types. For in vivo metabolism, I-125 labeled piperlongumine (125I-PL) was expelled by kidney soon post injection, so tumor targeting was achieved at 30 min post injection;125I-PL reached a 2.33 ± 0.51 ratio of tumor/liver in SMMC-7721 (HCC tumor cells line) subcutaneous tumor BALB/c nude mice, but a negative uptake was observed in MHCC97h subcutaneous tumor mice. Therefore, piperlongumine was conveniently synthesized via amidation approach, and the fast clearance and tumor targeting were manifested for the first time.
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影响因子：
2.1
作者：
Per M. Boll;J. Hansen;Ole Simonsen;N. Thorup
通讯作者：
Per M. Boll;J. Hansen;Ole Simonsen;N. Thorup
影响因子：
3.8
作者：
Qi Liu;Di Zhao;Xiaojie Zhu;Huili Chen;Yue Yang;Jiaqiu Xu;Qing Zhang;A. Fan;Ning Li;Chaorui Guo;Ying Kong;Yang Lu;Xijing Chen
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Qi Liu;Di Zhao;Xiaojie Zhu;Huili Chen;Yue Yang;Jiaqiu Xu;Qing Zhang;A. Fan;Ning Li;Chaorui Guo;Ying Kong;Yang Lu;Xijing Chen
影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
2.7
作者：
Y. Seo;Jin-Kyung Kim;J. Jun
通讯作者：
Y. Seo;Jin-Kyung Kim;J. Jun
影响因子：
3.2
作者：
Bezerra, Daniel Pereira;Gadelha Militao, Gardenia Carmen;Costa-Lotufo, Leticia Veras
通讯作者：
Costa-Lotufo, Leticia Veras