The role of tau kinases in Alzheimer's disease.
The role of tau kinases in Alzheimer's disease.
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发表时间：
2010-09
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通讯作者：
P. Dolan;G. Johnson
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作者：
P. Dolan;G. Johnson
阿尔茨海默病（AD）进展的主要特征是在受影响个体的脑中出现微管相关蛋白tau的异常磷酸化。重要的研究工作已经针对鉴定参与该过程的激酶，以及开发抑制这些分子的药理学试剂。本文综述了近年来tau蛋白磷酸化的生理和病理作用，以及磷酸化对AD中tau蛋白毒性和病理进展的作用。tau蛋白在细胞生物学中的作用以及磷酸化调节tau蛋白功能的机制的概念不断发展，正在重塑开发靶向tau蛋白治疗AD的治疗剂的框架。
A principal feature of the progression of Alzheimer's disease (AD) is the appearance of aberrant phosphorylation of the microtubule-associated protein tau in the brains of affected individuals. Significant research efforts have been directed at identifying the kinases involved in this process, as well as developing pharmacological agents to inhibit these molecules. This review focuses on recent developments in both the physiological and pathological effects of tau phosphorylation, and the contribution of phosphorylation to tau toxicity and pathological progression in AD. The evolving concepts of the roles tau plays in cellular biology, and the mechanisms by which phosphorylation regulates tau function, is reshaping the framework for the development of therapeutics targeting tau to treat AD.