Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends
Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends
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DOI：
10.1016/j.bbagen.2007.08.015
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发表时间：
2008-03-01
影响因子：
3
通讯作者：
Hakomori, Sen-Itiroh
中科院分区：
文献类型：
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作者：
Hakomori, Sen-Itiroh
基于各种糖鞘糖脂(GSLS)分离和表征方法的发展，我们已经鉴定了一些具有Globo系列或Lacto系列结构的GSLs。它们中的许多是肿瘤相关或发育调节的抗原。主要的问题出现了，它们在细胞和组织中的功能是什么？为回答这一问题采取了各种办法。虽然每种方法的方法不同，但我们一直在研究GSL或糖基表位与功能膜组件的相互作用，这些功能膜组件包括Tetraspanins、生长因子受体、整合素和信号转导分子。通常，GSLS被发现与特定的膜微域中的其他碳水化合物相互作用，该微域被称为“糖突触”，通过同时进行的信号转导来介导细胞黏附。讨论了GSL和糖基表位研究的未来趋势，包括干细胞生物学和上皮-间充质转化(EMT)过程。(C)2007 Elsevier B.V.保留所有权利。
Based on development of various methodologies for isolation and characterization of glycosphingolipids (GSLs), we have identified a number of GSLs with globo-series or lacto-series structure. Many of them are tumor-associated or developmentally regulated antigens. The major question arose, what are their functions in cells and tissues? Various approaches to answer this question were undertaken. While the method is different for each approach, we have continuously studied GSL or glycosyl epitope interaction with functional membrane components, which include tetraspanins, growth factor receptors, integrins, and signal transducer molecules. Often, GSLs were found to interact with other carbohydrates within a specific membrane microdomain termed "glycosynapse", which mediates cell adhesion with concurrent signal transduction. Future trends in GSL and glycosyl epitope research are considered, including stem cell biology and epithelial-mesenchymal transition (EMT) process. (c) 2007 Elsevier B.V. All rights reserved.