Exposure to multiple indoor allergens in US homes and its relationship to asthma
Exposure to multiple indoor allergens in US homes and its relationship to asthma
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DOI：
10.1016/j.jaci.2007.12.1164
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发表时间：
2008-03-01
影响因子：
14.2
通讯作者：
Zeldin, Darryl C.
中科院分区：
文献类型：
--
作者：
Salo, Paeivi M.;Arbes, Samuel J.;Zeldin, Darryl C.
背景：全国住房铅和过敏原调查是第一个以人口为基础的研究，以测量美国家庭室内过敏原水平。目的：我们描述了多种过敏原的总体负担，并检查过敏原水平的增加是否与居住者的哮喘状态有关。方法：这项横断面研究调查了全美75个不同地点的831个住房单元的全国代表性样本。通过问卷调查和环境评价等方式收集资料。用免疫分析法评估粉尘样品中的过敏原浓度。使用以下截断点来定义过敏原水平的增加：Der p1、Der f1和Can f1为10 μ g/g；Fel d1为8 μ g/g；blag1为8u /g；小鼠尿蛋白1.6 μ g/g；交替孢抗原为7 μ g/g。当4个或更多的过敏原在任何采样地点超过增加水平时，就认为过敏原负担高。结果：暴露于多种过敏原在美国家庭中很常见。在接受调查的家庭中，51.5%的家庭至少有6种可检测到的过敏原，45.8%的家庭至少有3种过敏原超标。种族、收入、住房类型、是否有孩子、是否有吸烟者、宠物、蟑螂、啮齿动物和霉菌/潮湿相关问题是高过敏原负担的独立预测因素。在特应性受试者中，高过敏原负担增加了出现哮喘症状的几率（优势比，1.81;95% CI, 1.04-3.15）。结论：家中过敏原水平的增加与过敏个体的哮喘症状有关。
Background: The National Survey of Lead and Allergens in Housing was the first population-based study to measure indoor allergen levels in US homes.Objective: We characterized the overall burden to multiple allergens and examined whether increased allergen levels were associated with occupants' asthma status.Methods: This cross-sectional study surveyed a nationally representative sample of 831 housing units in 75 different locations throughout the United States. Information was collected by means of questionnaire and environmental assessment. Allergen concentrations in dust samples were assessed by using immunoassays. The following cutoff points were used to define increased allergen levels: 10 mu g/g for Der p 1, Der f 1, and Can f 1; 8 mu g/g for Fel d 1; 8 U/g for Bla g 1; 1.6 mu g/g for mouse urinary protein; and 7 mu g/g for Alternaria alternata antigens. Allergen burden was considered high when 4 or more allergens exceeded increased levels in any of the sampling locations.Results: Exposure to multiple allergens was common in US homes. Of the surveyed homes, 51.5% had at least 6 detectable allergens and 45.8% had at least 3 allergens exceeding increased levels. Race, income, housing type, absence of children, and presence of smokers, pets, cockroaches, rodents, and mold/moisture-related problems were independent predictors of high allergen burden. Among atopic subjects, high allergen burden increased the odds of having asthma symptoms (odds ratio, 1.81; 95% CI, 1.04-3.15).Conclusion: Increased allergen levels in the home are associated with asthma symptoms in allergic individuals.