RELATION OF ARTERIAL-PRESSURE AND PLASMA ANGIOTENSIN-II CONCENTRATION - CHANGE PRODUCED BY PROLONGED INFUSION OF ANGIOTENSIN-II IN THE CONSCIOUS DOG
RELATION OF ARTERIAL-PRESSURE AND PLASMA ANGIOTENSIN-II CONCENTRATION - CHANGE PRODUCED BY PROLONGED INFUSION OF ANGIOTENSIN-II IN THE CONSCIOUS DOG
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DOI：
10.1161/01.res.44.4.452
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发表时间：
1979-01-01
影响因子：
20.1
通讯作者：
LEVER, AF
中科院分区：
文献类型：
--
作者：
BEAN, BL;BROWN, JJ;LEVER, AF
对未束缚的雄性比格犬（5只）连续静脉输注28天。首先，输注0.9%NaCl溶液7天，然后以每分钟3 ng/kg的速度输注血管紧张素II 14天，最后输注0.9%NaCl 7天。每只犬的血压逐渐升高，在血管紧张素II输注14天结束时达到峰值。停药后24 h内血压逐渐下降，5 d后血压降至最低。为了评估血浆血管紧张素II浓度与动脉压之间的关系，在第1次盐水输注期间、血管紧张素II输注7天和14天后以及第2次盐水输注结束时进行了剂量反应研究。以3、6和12 n/kg/min的速率静脉输注额外的血管紧张素II，每种速率持续1 h。动脉压的升高与血浆血管紧张素II浓度相关。在所有犬中，血管紧张素的长时间输注使曲线的位置向上移动。长时间输注血管紧张素提高了由给定的血管生成素II血浆浓度维持的压力水平。血管紧张素灌注后7天，曲线恢复到原始位置。在所有剂量反应研究中，血浆醛固酮浓度也增加。血管紧张素II和醛固酮的血浆浓度相关的回归曲线的斜率在长时间输注血管紧张素II后更陡。血浆K浓度在任何阶段均无变化。
Unrestrained male beagle dogs (5) were given a continuous i.v. infusion for 28 days. First, 0.9% NaCl solution was infused for 7 days, then angiotensin II at 3 ng/kg per min for 14 days and finally 0.9% NaCl for 7 days. The blood pressure rose gradually in each dog, reaching a peak toward the end of the 14 day infusion of angiotensin II. When angiotensin infusion was stopped, blood pressure fell gradually during 24 h; the lowest pressure was reached 5 days later. To assess the relation between plasma angiotensin II concentration and arterial pressure, dose-response studies were done during the 1st saline infusion, after 7 and 14 days of angiotensin II infusion, and at the end of the 2nd saline infusion. Additional angiotensin II was infused i.v. at 3, 6 and 12 n/kg per min, each rate for 1 h. The increase of arterial pressure was then related to concorrent plasma angiotensin II concentration. In all dogs, prolonged infusion of angiotensin shifted the position of the curve upward. Prolonged infusion of angiotensin raised the level of pressure maintained by a given plasma concentration of angiogensin II. The curve returned to the original position 7 days after the angiotensin infusion. Plasma aldosterone concentration also increased during all dose-response studies. The slope of the regression curve relating plasma concentrations of angiotensin II and aldosterone was steeper after prolonged infusion of angiotensin II. Plasma K concentration did not change at any stage.