THE CLINICAL UTILITY OF THE LUPUS BAND TEST
THE CLINICAL UTILITY OF THE LUPUS BAND TEST
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DOI：
10.1002/art.1780270404
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发表时间：
1984-01-01
影响因子：
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通讯作者：
ROTHFIELD, NF
中科院分区：
文献类型：
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作者：
SMITH, CD;MARINO, C;ROTHFIELD, NF
为探讨狼疮带试验的临床应用价值，对102例系统性红斑狼疮(SLE)和151例其他风湿病患者的皮肤活检标本进行了真皮-表皮交界处(DEJ)的免疫球蛋白、免疫球蛋白M、免疫球蛋白A、补体C3、补体C4、补体C1q和备解素的检测。72.6%(74/102)的SLE患者和36.4%(55/151)的其他患者在DEJ处检测到一种或多种蛋白质，其特异度为%，预测值为57%。对SLE的预测价值以C4(100%)、备解素(91.3%)和IgA(86.2%)最高，而IgM(59%)最低。在DEJ检测到的蛋白质数量越多，特异性和预测值越高。在狼疮带试验的阳性结果具有诊断意义之前，需要更严格的标准。
To determine the clinical utility of the lupus band test, the presence of dermal-epidermal junction (DEJ) deposits of IgG, IgM, IgA, C3 [complement componet 3] C4, C1q and properdin were studied in biopsies of clinically normal deltoid area skin from 102 patients with systemic lupus erythematosus (SLE) and 151 patients with other rheumatic diseases. One or more proteins were detected at the DEJ in 72.6% (74 of 102) of patients with SLE and in 36.4% (55 of 151) of the other patients, yielding a specificity of 64% and a predictive value of 57%. The predictive value for the diagnosis of SLE was greatest with C4 (100%), properdin (91.3%) and IgA (86.2%) and lowest with IgM (59%). Specificity and predictive value increased with the number of proteins detected at the DEJ. More rigid criteria are required before diagnostic significance is attached to a positive result on the lupus band test.