SERUM C-REACTIVE PROTEIN-LEVELS IN DISEASE
SERUM C-REACTIVE PROTEIN-LEVELS IN DISEASE
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DOI：
10.1111/j.1749-6632.1982.tb22153.x
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发表时间：
1982-01-01
影响因子：
5.2
通讯作者：
KUSHNER, I
中科院分区：
文献类型：
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作者：
MORLEY, JJ;KUSHNER, I
C-反应蛋白(CRP)是一种源于肝脏的血浆蛋白，在组织损伤或感染后，其浓度可能会迅速上升到正常水平的1000倍以上。虽然这种蛋白的确切生物学作用尚不清楚，但最近的证据表明，它可以表现出识别和激活功能，并可能影响炎症。一段时间以来，人们一直在评估血清中CRP的潜在临床用途。然而，直到最近，广泛使用的检测CRP的方法充其量是半定量的，限制了它们的严重性。在使用这种方法的早期研究中(例如，5，6)，血清CRP经常被简单地报告为“不存在”或“存在”或“升高”。这些术语的使用与以前的观点是一致的，即健康人的血清中通常不存在CRP，仅仅它的存在就具有病理意义。然而，最近十年的研究表明，在所有正常个体的血清中都可以检测到CRP。因此，很明显，关于CRP的关键临床问题不是是否存在，而是存在多少。最近引入的两种方法，径向免疫扩散法和散射比浊法允许在临床重要范围内对血清CRP水平进行精确的定量评估。这种定量能力的可获得性强调了我们相对缺乏关于人类不同程度的CRP升高的临床意义的信息。由于已发表的定量CRP数据的报道仅限于相对较少的特定疾病状态，因此本研究旨在提供有关不同疾病的住院患者中不同程度的CRP升高的进一步信息。此外，我们还将回顾一些已发表的关于定量测定CRP在各种特定疾病的诊断中的有效性的报道。
C-reactive protein (CRP) is a plasma protein of hepatic origin whose concentration may rapidly increase to levels more than 1000 times normal following tissue injury or infection.’While the precise biologic role of this protein is unclear, recent evidence has shown that it can exhibit recognition and activation functions with the potential for influencing inflammation.’The potential clinical usefulness of estimation of CRP in serum has been appreciated for some time. Until recently, however, the methods in widespread use for detection of CRP were semiquantitative at best, limiting their~ sefulness.~~~ In early studies employing such methods (eg, 5, 6), serum CRP was often reported as simply “absent” or “present” or “elevated.” The use of such terms was consistent with previously held views that CRP was normally absent from the serum of healthy individuals and that its mere presence had pathological significance. However, it has been shown in the last decade that CRP can be detected in serum from all normal individ~ als.~.’It is thus clear that the critical clinical question about CRP is not whether it is present, but how much is present.Two recently introduced methods, radial immun~ diffusion~ and nephelomepermit precise quantitative assessment of serum CRP levels in the range of clinical importance. The availability of this quantitative capability has underscored our relative lack of information about the clinical significance of differing degrees of CRP elevation in man. Since published reports of quantitative CRP data have been confined to relatively few specific disease states, the present study was undertaken to provide further information about the varying degrees of CRP elevation in a broad spectrum of hospitalized patients with different diseases. In addition, we will review some published reports of the usefulness of quantitative CRP determination in diagnosis of management of various specific diseases.