The clinical relevance of opiate receptor research
The clinical relevance of opiate receptor research
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DOI：
10.1002/ddr.430010405
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发表时间：
1981
影响因子：
3.8
通讯作者：
A. P. Smith;H. Loh
中科院分区：
文献类型：
--
作者：
A. P. Smith;H. Loh
阿片受体研究的最新进展，特别是相关的临床医生进行了讨论。一个简单的结合试验，这本身是有价值的，允许快速筛选新的化合物的阿片活性，一直是这些研究的基础。广泛的映射阿片受体在皮层下的大脑区域提供了重要的见解参与镇痛的神经元通路，而这些受体的物理和化学特性导致了一个简单的手段，区分激动剂拮抗剂。多种受体的存在表明，阿片类药物的镇痛作用可能与其他作用无关，耐受性和依赖性研究表明，它们也可能与镇痛无关。受体的纯化，至少是一个合理的可能性，可能会导致新的方法来促进或抑制镇痛。
Recent progress in opiate receptor research of particular relevance to clinicians is discussed. A simple binding assay, which in itself is valuable in allowing rapid screening of new compounds for opiate activity, has been the basis of these studies. Extensive mapping of opiate receptors in subcortical brain regions has provided important insights into the neuronal pathways involved in analgesia, while physical and chemical characterization of these receptors has led to a simple means of distinguishing agonists from antagonists. The existence of multiple receptors suggests that the analgetic effects of the opiates may be dissociated from other effects, and studies of tolerance and dependence indicate that they too may be dissociable from analgesia. Purification of the receptors, at last a reasonable possibility, may lead to new ways to promote or inhibit analgesia.