Comparative anatomy of mammalian conjunctival lymphoid tissue: A putative mucosal immune site
Comparative anatomy of mammalian conjunctival lymphoid tissue: A putative mucosal immune site
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DOI：
10.1016/s0145-305x(98)00022-6
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发表时间：
1998-09-01
影响因子：
2.9
通讯作者：
Kennedy, RC
中科院分区：
文献类型：
--
作者：
Chodosh, J;Nordquist, RE;Kennedy, RC
组织化粘膜相关淋巴组织（O-MALT）是由粘膜淋巴滤泡及其上覆的淋巴上皮细胞所定义的，典型地出现在具有单层柱状上皮的组织中。在滤泡相关上皮内，杯状细胞特征性地缺失，被超微结构上不同的抗原吸收细胞所取代，由于其顶端细胞膜的出现而被称为M细胞（或微褶细胞）。为了确定哺乳动物结膜及其复层鳞状上皮是否可以被视为O-MALT的部位，我们比较了14种非人类成年哺乳动物结膜的光学和电子显微镜解剖结构，以及尸检时收获的人类成年人结膜。除小鼠和大鼠外，在所有研究的哺乳动物中均发现结膜中的类滤泡。在这些哺乳动物的结膜淋巴滤泡，滤泡相关的结膜上皮是值得注意的杯状细胞的情况下，透射电子显微镜表明，淋巴细胞与表面上皮细胞的密切联系，但上皮细胞形态均匀覆盖的滤泡，和M细胞的其他超微结构特征是缺席。因此，结膜淋巴滤泡相关复层鳞状上皮显示了O-MALT淋巴上皮的一些但不是全部特征。结膜淋巴组织在粘膜免疫中的作用有待进一步研究。(C)1998爱思唯尔科技有限公司版权所有。
Organized mucosa-associated lymphoid tissue (O-MALT) is defined by mucosal lymphoid follicles with unique overlying lymphoepithelia, and classically appears in tissues with a simple columnar epithelium, Within follicle-associated epithelium, goblet cells are characteristically absent, replaced by ultrastructurally distinct antigen-absorptive cells, termed M cells (or microfold cells) for the appearance of their apical cell membranes. To determine if mammalian conjunctiva, with its stratified squamous epithelium, can be considered as a site of O-MALT, we compared the Light and electron microscopic anatomy of conjunctiva from fourteen species of non-human adult mammals, and the conjunctiva of human adults harvested at autopsy. Lymphoid follicles in the conjunctiva were demonstrated in all mammals studied except for mice and rats. In those mammals with conjunctival lymphoid follicles, the follicle-associated conjunctival epithelium was notable for an absence of goblet cells, Transmission electron microscopy demonstrated an intimate association of lymphocytes with surface epithelial cells, but epithelial cell morphology was uniform overlying the follicle, and other ultrastructural features of M cells were absent. Therefore, conjunctival lymphoid follicle-associated stratified squamous epithelium demonstrates some but not all features of O-MALT lymphoepithelia. Further studies are necessary to determine what role conjunctival lymphoid tissue may play in mucosal immunity. (C) 1998 Elsevier Science Ltd. All rights reserved.