Cardiac abnormalities in HIV-positive patients: results from an observational study in India.
Cardiac abnormalities in HIV-positive patients: results from an observational study in India.
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DOI：
10.1177/1545109712456740
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Gupta, Alok
中科院分区：
文献类型：
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作者：
Jain, Nirdesh;Reddy, Dandu H;Gupta, Alok
背景：hiv感染患者心脏异常的临床表现可能不典型或被并发疾病掩盖，导致误诊或未确诊；因此，本研究旨在确定hiv感染患者心脏异常的频率。材料与方法：在征得患者同意后，对年龄在bb0 ~ 13岁的连续hiv感染患者进行为期3个月的研究。临床评估后进行胸片、心电图、二维超声心动图及血清肌钙蛋白T水平检测。结果：共研究100例患者，其中x线片见心脏增大者占15%，心电图异常者占18%，二维超声异常者占67%；最常见的异常是舒张功能不全（42.8%），其次是扩张性心肌病（17.6%）。血清肌钙蛋白T升高8%。机会性感染（OIs）、抗逆转录病毒治疗（ART）、HIV疾病分期和CD4计数等变量不影响舒张功能障碍的发生频率。结论：舒张功能不全是hiv感染者最常见的心脏异常。
BACKGROUND: The clinical presentation of cardiac abnormalities in HIV-infected patients may be atypical or masked by concurrent illnesses that lead to misdiagnosis or they remain undiagnosed; therefore, this study was aimed to determine the frequency of cardiac abnormalities in HIV-infected patients.MATERIAL AND METHODS: Consecutive HIV-infected patients of age >13 years were studied for 3 months, after obtaining their consent. After clinical assessment, chest x-ray, electrocardiogram, 2-dimensional echocardiography and serum Troponin T levels were done.RESULTS: A total of 100 patients were studied, cardiomegaly was observed in the x-ray of 15% of them, abnormal electrocardiogram was seen in 18%, 2-dimensional echocardiography was abnormal in 67%; and diastolic dysfunction (42.8%) was the commonest abnormality followed by dilated cardiomyopathy (17.6%). Serum troponin T was elevated in 8%. The variables, opportunistic infections (OIs), antiretroviral therapy (ART), stage of HIV disease, and CD4 counts, did not affect the frequency of diastolic dysfunction.CONCLUSION: The diastolic dysfunction is the most common cardiac abnormality observed in HIV-infected patients.