Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus.
Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus.
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DOI：
10.1016/j.metop.2020.100032
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发表时间：
2020-06-01
期刊：
影响因子：
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通讯作者：
Kadowaki, Takashi
中科院分区：
文献类型：
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作者：
Kobayashi, Yuka;Suzuki, Ryo;Kadowaki, Takashi
Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3±4.1% vs 26.2±5.1%) and nephropathy (24.1±3.9%, 24.6±4.2%, 28.5±6.1%, 31.3±5.7%, 37.8±2.9%, stage 1/2/3/4/5, respectively). These findings highlight the universal importance of oxidative stress, indicating HNA% potential as a versatile marker of the severity of diabetic complications.
