ROLES OF N-TYPE AND Q-TYPE CA2+ CHANNELS IN SUPPORTING HIPPOCAMPAL SYNAPTIC TRANSMISSION
ROLES OF N-TYPE AND Q-TYPE CA2+ CHANNELS IN SUPPORTING HIPPOCAMPAL SYNAPTIC TRANSMISSION
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DOI：
10.1126/science.7832825
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发表时间：
1994-04-01
期刊：
影响因子：
56.9
通讯作者：
TSIEN, RW
中科院分区：
文献类型：
--
作者：
WHEELER, DB;RANDALL, A;TSIEN, RW
在中枢神经系统中发现的几种类型的钙通道可能参与触发神经递质释放。海马CA 3和CA 1神经元之间的突触传递是由N型钙通道介导的，以及其药理学不同于L-和P-型通道但类似于α 1A亚基基因编码的Q-型通道的钙通道。阻断任何人口的渠道强烈增加增强突触传递与重复刺激。即使在完全阻断N型通道后，神经递质受体或蛋白激酶C的刺激也能强烈调节传递。这些发现表明α 1A亚基在突触传递中的作用，并支持神经递质释放可能取决于生理条件下的多种类型的钙通道的想法。
Several types of calcium channels found in the central nervous system are possible participants in triggering neurotransmitter release. Synaptic transmission between hippocampal CA3 and CA1 neurons was mediated by N-type calcium channels, together with calcium channels whose pharmacology differs from that of L- and P-type channels but resembles that of the Q-type channel encoded by the alpha1A subunit gene. Blockade of either population of channels strongly increased enhancement of synaptic transmission with repetitive stimuli. Even after complete blockade of N-type channels, transmission was strongly modulated by stimulation of neurotransmitter receptors or protein kinase C. These findings suggest a role for alpha1A subunits in synaptic transmission and support the idea that neurotransmitter release may depend on multiple types of calcium channels under physiological conditions.