INVITRO AND INVIVO METAL-ION RELEASE
INVITRO AND INVIVO METAL-ION RELEASE
复制标题
体外及体内金属离子释放情况
DOI：
10.1002/jbm.820220406
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发表时间：
1988-04-01
期刊：
影响因子：
--
通讯作者：
CROWE, TD
中科院分区：
文献类型：
--
作者：
BROWN, SA;FARNSWORTH, LJ;CROWE, TD
通过一系列的实验研究了金属离子的体外释放和体内释放以及金属离子的尿排泄。注射金属盐并分析尿液。阳极电位施加到不锈钢和钴-铬-钼（CCM）标本，造成加速的腐蚀速率。在生理盐水、10%血清和仓鼠皮下空间中进行腐蚀实验。腐蚀速率通过测量重量损失和计算净电荷转移来确定。金属离子浓度在石墨炉原子吸收光谱法中测定，并使用法拉第定律从总电荷计算。不锈钢的结果表明，体外和体内不锈钢的重量损失和金属离子释放可以使用法拉第定律计算，假设释放与合金成分成比例。CCM的结果表明，体外释放速率可用于确定体内释放比例。所有的镍和大部分的钴被迅速排出，而不到50%的铬被排出。盐注射或体内腐蚀后的金属排泄非常相似。
A series of experiments was conducted to study in vitro and in vivo metal ion release and the urine excretion of metal ions. Metal salts were injected and urine analyzed. Anodic potentials were applied to stainless steel and cobalt-chromium-molybdenum (CCM) specimens to cause an acceleration of corrosion rates. Corrosion experiments were done in saline, 10% serum and in a subcutaneous space in hamsters. Corrosion rates were determined by measurements of weight loss and calculations of net charge transfer. Metal ion concentrations were determined in graphite furnace atomic absorption spectroscopy, and were calculated from total charge using Faraday''s law. The results with stainless steel showed that the weight loss and metal ion release from stainless steel in vitro and in vivo can be calculated using Faraday''s Law, assuming release in proportion to alloy composition. The results with CCM indicated that release rates in vitro can be used to determine the proportionality of release in vivo. All the nickel and most of the cobalt was rapidly excreted, while less than 50% of the chromium was excreted. The excretion of metals following salt injection or in vivo corrosion were very similar.