EFFECT OF THE LATE COMPLEMENT COMPONENTS-C5B-9 ON HUMAN-MONOCYTES - RELEASE OF PROSTANOIDS, OXYGEN RADICALS AND OF A FACTOR INDUCING CELL-PROLIFERATION
EFFECT OF THE LATE COMPLEMENT COMPONENTS-C5B-9 ON HUMAN-MONOCYTES - RELEASE OF PROSTANOIDS, OXYGEN RADICALS AND OF A FACTOR INDUCING CELL-PROLIFERATION
复制标题
DOI：
10.1159/000234216
复制
发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
BETZ, M
中科院分区：
文献类型：
--
作者：
HANSCH, GM;SEITZ, M;BETZ, M
最近，我们报道了分离的C5 b-9刺激大鼠巨噬细胞和人血小板合成前列腺素E（PGE）或血栓烷B2（TXB 2）。在本研究中，我们测试了除了前列腺素外，C5 b-9是否也会诱导其他介质的产生。我们发现，C5 b-9亚溶浓度刺激人粒细胞（多形核白细胞）或单核细胞释放氧自由基。此外，单核细胞响应C5 b-9释放白细胞介素-1。因此，除了具有溶解能力之外，C5 b-9还充当各种细胞的刺激物。
Recently, we reported stimulation of rat macrophages and human platelets by isolated C5b-9 to synthesize prostaglandin E (PGE) or thromboxane B2(TXB2). In the present study, we tested whether besides prostanoids, C5b-9 also would induce the production of other mediators. We found that C5b-9 in sublytic concentrations stimulated human granulocytes (polymorphonuclear leukocytes) or monocytes to release oxygen radicals. Furthermore, monocytes release interleukin-1 in response to C5b-9. Thus, besides having a lytic capacity, C5b-9 also functions as a stimulator of various cells.