Zinc-catalyzed synthesis of pyrazolines and pyrazoles via hydrohydrazination
Zinc-catalyzed synthesis of pyrazolines and pyrazoles via hydrohydrazination
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DOI：
10.1021/ol800592s
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发表时间：
2008-06-19
期刊：
影响因子：
5.2
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Alex, Karolin;Tillack, Annegret;Beller, Matthias
发展了一种新的芳基取代吡唑和吡唑的区域选择性合成方法。取代苯肼与3-丁醇在催化量的三氟化锌存在下反应生成吡唑啉衍生物。生成的产物很容易在一锅法中氧化成相应的吡唑。
A novel regioselective synthesis of aryl-substituted pyrazolines and pyrazoles has been developed. Substituted phenylhydrazines react with 3-butynol in the presence of a catalytic amount of zinc triflate to give pyrazoline derivatives. The resulting products are easily oxidized in a one-pot procedure to the corresponding pyrazoles.