Shock wave application to rat skin induces degeneration and reinnervation of sensory nerve fibres
Shock wave application to rat skin induces degeneration and reinnervation of sensory nerve fibres
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DOI：
10.1016/s0304-3940(01)02320-5
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发表时间：
2001-11-23
影响因子：
2.5
通讯作者：
Moriya, H
中科院分区：
文献类型：
--
作者：
Ohtori, S;Inoue, G;Moriya, H
已经有一些关于体外冲击波用于治疗假关节、钙化性肌腱炎和肘部肌腱病的报道。然而，疼痛缓解的病理机制尚不清楚。为了研究冲击波的止痛特性，我们分析了冲击波是否会引起皮肤神经纤维的形态变化。在正常大鼠皮肤中，表皮主要由蛋白基因产物(PGP)9.5免疫反应阳性的神经纤维和降钙素基因相关肽(CGRP)免疫反应阳性的神经纤维支配。经冲击波处理的皮肤中的表皮神经纤维几乎完全变性，PGP 9.5或CGRP免疫反应丧失。治疗2周后，表皮神经重新支配。这些数据表明，冲击波作用于皮肤后疼痛的缓解是由于皮内神经纤维的快速退化所致。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
There have been several reports on the use of extracorporeal shock waves in the treatment of pseudarthrosis, calcifying tendinitis, and tendinopathies of the elbow. However, the pathomechanism of pain relief has not been clarified. To investigate the analgesic properties of shock wave application, we analyzed whether it produces morphologic changes in cutaneous nerve fibres. In normal rat skin, the epidermis is heavily innervated by nerve fibres immunoreactive for protein gene product (PGP) 9.5 and by some fibres immunoreactive for calcitonin gene-related peptide (CGRP). There was nearly complete degeneration of epidermal nerve fibres in the shock wave-treated skin, as indicated by the loss of immunoreactivity for PGP 9.5 or CGRP. Reinnervation of the epidermis occurred 2 weeks after treatment. These data show that relief of pain after shock wave application to the skin results from rapid degeneration of the intracutaneous nerve fibres. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.