Effect of postthrombotic syndrome on health-related quality of life after deep venous thrombosis
Effect of postthrombotic syndrome on health-related quality of life after deep venous thrombosis
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DOI：
10.1001/archinte.162.10.1144
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发表时间：
2002-05-27
影响因子：
--
通讯作者：
Shrier, I
中科院分区：
文献类型：
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作者：
Kahn, SR;Hirsch, A;Shrier, I
背景：血栓后综合征(PTS)是深静脉血栓形成的常见慢性并发症，但其对健康相关生活质量的影响尚未得到很好的描述。我们比较了患有PTS和不患有PTS的患者的一般和静脉疾病特有的生活质量，并评估生活质量是否与PTS的严重程度相关。方法：以既往有深静脉血栓形成的受试者为研究对象，研究运动对深静脉血栓形成的影响。我们使用经过验证的临床量表来确定PTS及其严重程度。受试者完成了一般的(36个条目的简短健康调查)和特定的疾病(静脉功能不全流行病学和经济研究生活质量问卷[VEINES-QOL]及其关于静脉症状的10个条目的有效子量表[VEINES-SYM])的生活质量测量。结果：在41例受试者(平均年龄51.2岁)中，19例(46%)患有PTS。PTS患者的疾病特异性生活质量评分显著低于非PTS患者(平均+/-SD静脉生活质量评分，分别为44.5+/-11.6和54.8+/-5.4，P
Background: Postthrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis, yet its impact on health-related quality of life has not been well characterized. We compared generic and venous disease-specific quality of life in patients with and without PTS, and assessed whether quality of life correlated with severity of PTS.Methods: Subjects with previous deep venous thrombosis were participants in a study of the effects of exercise after deep venous thrombosis. We ascertained PTS and its severity using a validated clinical scale. Subjects completed generic (the 36-Item Short-Form Health Survey) and disease-specific (Venous Insufficiency Epidemiologic and Economic Study quality-of-life questionnaire [VEINES-QOL] and its validated subscale of 10 items on venous symptoms [ VEINES-Sym]) quality-of-life measures. Age- and sex-adjusted mean quality-of-life scores were compared in patients with and without PTS, and by severity of PTS.Results: Of the 41 subjects (mean age, 51.2 years), 19 (46%) had PTS. Subjects with PTS had significantly worse disease-specific qualily-of-life scores than those without PTS (mean+/-SD VEINES-QOL score, 44.5+/-11.6 vs 54.8+/-5.4, respectively [P