OVER-EXPRESSION OF THE EGF RECEPTOR IS A HALLMARK OF SQUAMOUS-CELL CARCINOMAS
OVER-EXPRESSION OF THE EGF RECEPTOR IS A HALLMARK OF SQUAMOUS-CELL CARCINOMAS
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DOI：
10.1002/path.1711490104
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发表时间：
1986-05-01
影响因子：
7.3
通讯作者：
GUSTERSON, B
中科院分区：
文献类型：
--
作者：
OZANNE, B;RICHARDS, CS;GUSTERSON, B
当EGF结合到受体的胞外区时，它会刺激与受体胞内区相关的酪氨酸特异性蛋白激酶活性。这导致EGF受体的自磷酸化和几种靶蛋白的磷酸化。不同类型的细胞表达不同数量的细胞表面EGF受体，从淋巴细胞上没有到角质形成细胞上高达25万个/细胞。角质形成细胞上高水平的EGF受体突显了EGF在组织培养和体内调节表皮细胞生长和分化中的重要作用。在组织培养中
When EGF binds to the extracellular domain of the receptor it stimulates the tyrosine specific protein kinase activity associated with the intracellular domain of the recept~ r.~-~ This results in the autophosphorylation of the EGF receptor and phosphorylation of several target protein^.^,^ Different cell types express different numbers of cell surface EGF receptors from none on lymphoid cells to a high of 250 000 per cell on keratinocytes. 8-10 The high level of EGF receptors on keratinocytes highlights the important role EGF plays in regulating the growth and differentiation of epidermal cells both in tissue culture and in vivo. In tissue culture