Effect of Non-Newtonian Behavior on Hemodynamics of Cerebral Aneurysms
Effect of Non-Newtonian Behavior on Hemodynamics of Cerebral Aneurysms
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DOI：
10.1115/1.3148470
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发表时间：
2009-09-01
影响因子：
1.7
通讯作者：
Rossmann, Jenn Stroud
中科院分区：
文献类型：
--
作者：
Fisher, Carolyn;Rossmann, Jenn Stroud
脑动脉瘤附近和内部的血流动力学长期以来与动脉瘤生长和破裂有关。在这项研究中，脉动流的控制方程在其有限体积公式中求解，以模拟一系列三维动脉瘤几何形状中的血流。四个本构模型被用来研究非牛顿行为的流动模式和流体机械力的影响。血液的非牛顿行为被发现是更显着的，特别是血管的几何形状，并有明显的影响动脉瘤内的流动和流体机械力。本构模型的选择对流体应力引起的动脉瘤破裂风险的数值预测具有可测量的影响，但影响小于动脉瘤形态。[DOI：10.1115/1.3148470]
Blood flow dynamics near and within cerebral aneurysms have long been implicated in aneurysm growth and rupture. In this study, the governing equations for pulsatile flow are solved in their finite volume formulation to simulate blood flow in a range of three-dimensional aneurysm geometries. Four constitutive models are applied to investigate the influence of non-Newtonian behavior on flow patterns and fluid mechanical forces. The bloods non-Newtonian behavior is found to be more significant, in particular vascular geometries, and to have pronounced effects on flow and fluid mechanical forces within the aneurysm. The choice of constitutive model has measurable influence on the numerical prediction of aneurysm rupture risk due to fluid stresses, though less influence than aneurysm morphology. [DOI: 10.1115/1.3148470]