Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment.
Risk of hepatocellular carcinoma in hepatitis B and prevention through treatment.
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DOI：
10.3949/ccjm.76.s3.02
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发表时间：
2009-05-01
影响因子：
6.1
通讯作者：
Sherman, Morris
中科院分区：
文献类型：
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作者：
Sherman, Morris
慢性B型肝炎病毒（HBV）感染患者发生肝细胞癌的危险因素正在阐明。HBV DNA浓度大于10（4）拷贝/毫升是一个特别强的预测风险的个体年龄在30岁或以上，独立于血清丙氨酸氨基转移酶（ALT）水平。其他癌症的预测因子是HBV基因型，其中基因型C赋予增加的风险，血清ALT值至少是正常上限的两倍。持续拉米夫定治疗的病毒抑制可以降低并发症的风险，并在维持应答的情况下延缓肝病的进展。
Risk factors for the development of hepatocellular carcinoma in patients with chronic hepatitis B virus (HBV) infection are being elucidated. An HBV DNA concentration greater than 10(4) copies/mL is an especially strong predictor of risk in individuals aged 30 years or older, independent of the level of serum alanine aminotransferase (ALT). Other predictors of cancer are HBV genotype, with genotype C imparting an increased risk, and serum ALT values at least two times the upper limit of normal. Viral suppression with continuous lamivudine therapy reduces the risk of complications and delays progression of liver disease as long as response is maintained.