Experimental Models of Anxiety for Drug Discovery and Brain Research
Experimental Models of Anxiety for Drug Discovery and Brain Research
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DOI：
10.1007/978-1-4939-3661-8_16
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Kalueff, Allan V.
中科院分区：
文献类型：
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作者：
Hart, Peter C.;Bergner, Carisa L.;Kalueff, Allan V.
动物模型对于实验神经科学的近期进展至关重要，包括对常见人类脑部疾病（如焦虑、抑郁和精神分裂症）的建模。由于小鼠在暴露于应激源（例如新环境、强光或社交冲突）时会表现出强烈的类焦虑行为，这些表型在测试精神药物的效果方面具有明显的实用性。特别令人感兴趣的是小鼠模型可在多大程度上用于筛选新的抗焦虑药物以及验证它们在人类中的可能应用。为了解决这个问题，本章将回顾小鼠焦虑的不同实验模型，并讨论它们在测试抗焦虑和致焦虑药物方面的实用性。将为这些范例提供详细的实验方案，并相应地解决可能存在的干扰因素。
Animal models have been vital to recent advances in experimental neuroscience, including the modeling of common human brain disorders such as anxiety, depression, and schizophrenia. As mice express robust anxiety-like behaviors when exposed to stressors (e.g., novelty, bright light, or social confrontation), these phenotypes have clear utility in testing the effects of psychotropic drugs. Of specific interest is the extent to which mouse models can be used for the screening of new anxiolytic drugs and verification of their possible applications in humans. To address this problem, the present chapter will review different experimental models of mouse anxiety and discuss their utility for testing anxiolytic and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds will be addressed accordingly.