Metabolic, Hormonal, and Vascular Changes after Synthetic Oestrogen Therapy in Oophorectomized Women
Metabolic, Hormonal, and Vascular Changes after Synthetic Oestrogen Therapy in Oophorectomized Women
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卵巢切除女性合成雌激素治疗后的代谢、激素和血管变化
DOI：
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发表时间：
1971
影响因子：
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通讯作者：
I. Macgillivray
中科院分区：
文献类型：
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作者：
S. Gow;I. Macgillivray
25例卵巢切除妇女服用炔雌醇的三甲基醚形式，也是口服类固醇避孕药中使用的两种雌激素之一，剂量为0.02 mg/d，共120天。尿雌三醇和孕激素排泄不受美雌醇治疗的影响，但阴道涂片的成熟指数向右偏移，表明治疗前雌激素缺乏症得到纠正。在相对较短的给药期间，血压或心电图记录未发生显著变化。血清蛋白结合碘显著升高，这可能被认为是长期使用美雌醇的不良反应。通过溴磺酞测定的肝功能未因给药而受损。美雌醇对妇女的总身体水分或总交换性钾没有影响。它的两个最严重的副作用是葡萄糖耐量受损和静脉血栓栓塞性疾病的高发病率（16%）。不良反应的严重性远远超过任何有益的，并排除了使用美雌醇单独作为长期激素替代治疗绝经后妇女。
Mestranol, the three-methyl ether form of ethinyloestradiol and one of the two oestrogens used in oral contraceptive steroids, was administered in a dose of 0·02 mg daily for 120 days to 25 oophorectomized women. Urinary oestriol and pregnanediol excretions were unaffected by the mestranol treatment but there was a shift of the maturation index of the vaginal smear to the right, indicating a correction of the pretreatment oestrogen deficiency. No significant change in the blood pressure or electrocardiograph recordings occurred during this relatively short period of administration. A significant rise in the serum protein-bound iodine, which might be regarded as an undesirable effect of mestranol on a long-term basis, occurred. Hepatic function as measured by bromsulphthalein was not impaired by the treatment. Mestranol had no effect on the total body water or on the total exchangeable potassium of the women. Its two most serious adverse effects were impairment of glucose tolerance and a high incidence (16%) of venous thrombo-embolic disease. The gravity of the adverse effects far outweighs any beneficial ones and precludes the use of mestranol alone for long-term hormone replacement therapy in postmenopausal women.