Eating disorders: a situation of malnutrition with peculiar changes in the immune system
Eating disorders: a situation of malnutrition with peculiar changes in the immune system
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DOI：
10.1038/sj.ejcn.1600987
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发表时间：
2000-03-01
影响因子：
4.7
通讯作者：
Marcos, A
中科院分区：
文献类型：
--
作者：
Marcos, A
进食障碍，如神经性厌食症和神经性贪食症，是大部分人口的重大公共卫生问题，因此甚至被认为是流行病。这些综合征有一个共同的目的：追求理想的和极低的体重，这显然是非常远离理想的体重。因此，这些患者表现出异常的饮食行为，导致营养不良的情况。营养素在免疫系统的发育和功能中起着重要作用。因此，免疫学参数的评估获得了极大的兴趣，作为一个有用的工具，以评估这些患者的营养状况。此外，众所周知，营养不良导致的免疫系统衰竭与感染易感性增加有关。然而，大量文献指出，腹泻患者尽管严重营养不良，但相对而言不容易感染传染病。由于免疫系统被扭曲的食物行为改变，例如在饮食失调的情况下，了解这些病理中涉及的其他系统的特征，因此改变，将非常有助于理解这些综合征中触发的机制。事实上，免疫系统和饮食失调症中其他系统之间的相互作用正在开始研究。最后，主要目标是通过早期诊断和适当的治疗来限制这些疾病的发展，以便随后为患者提供持续和明确的治疗。
Eating disorders, such as anorexia nervosa and bulimia nervosa, are significant public health concerns for a great deal of the population, and thus are even considered to be epidemics. These syndromes have a common aim: the pursuit of a desirable and extremely low weight, which is obviously very far from the ideal body weight. Therefore, these patients show abnormal food behavior, leading to a situation of malnutrition. Nutrients play an important role in the development and functionality of the immune system. Thus, the assessment of immunological parameters acquires great interest as a useful tool to evaluate the nutritional status of these patients. In addition, it is very well known that a depleted immune system as a consequence of malnutrition is linked to an increased susceptibility to infections. However, an extensive literature has pointed out that anorexic patients, even though severely malnourished, are relatively free from infectious diseases. As the immune system is altered by distorted food behaviors, such as in case of eating disorders, the awareness of the characteristics of other systems involved in these pathologies, and therefore altered, would be very helpful for the understanding of the mechanisms triggered in these syndromes. In fact, the interactions among the immune system and the remaining systems in eating disorders are beginning to be studied. Finally, the main goal is to limit the evolution of these illnesses through an early diagnosis and appropriate therapy to subsequently get a constant and definitive cure for the patients.