Telling cells how to die -: Docetaxel therapy in cancer cell lines
Telling cells how to die -: Docetaxel therapy in cancer cell lines
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DOI：
10.4161/cc.6.7.4050
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发表时间：
2007-04-01
期刊：
影响因子：
4.3
通讯作者：
Moreno-Bueno, Gema
中科院分区：
文献类型：
--
作者：
Hernandez-Vargas, Hector;Palacios, Jose;Moreno-Bueno, Gema
紫杉烷(紫杉醇和多西紫杉醇)是用于治疗实体肿瘤的临床实践中使用的抗微管药物。紫杉烷依赖的细胞毒性的分子机制仅部分为人所知。在体外，根据紫杉醇浓度的不同，已经建立了不同的作用模式。包括多西紫杉醇在内的其他稳定微管的药物也出现了类似的现象。最近，我们描述了暴露于多西他赛的乳腺癌细胞株中两种不同形式的有丝分裂退出。文中讨论了该制剂细胞毒性双重机制的原因和后果。
Taxanes ( paclitaxel and docetaxel) are antimicrotubule agents used in the clinical practice for the treatment of solid tumors. The molecular mechanisms of taxane-dependent cytotoxicity are only partially known. In vitro, different modes of action have been established for paclitaxel according to its concentration. A similar phenomenon has been shown for other microtubule-stabilizing drugs, including docetaxel. Recently, we described two different forms of mitotic exit in breast cancer cell lines exposed to docetaxel. The causes and consequences of the dual mechanism of cytotoxicity of this agent are discussed here.