Progesterone and 20 alpha-hydroxyprogesterone stimulate the in vitro release of GnRH by the isolated mediobasal hypothalamus.
Progesterone and 20 alpha-hydroxyprogesterone stimulate the in vitro release of GnRH by the isolated mediobasal hypothalamus.
复制标题
黄体酮和 20α-羟基黄体酮刺激离体的下丘脑内侧基底层体外释放 GnRH。
DOI：
10.1016/0024-3205(83)90919-0
复制
发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
Yen,SS
中科院分区：
文献类型：
--
作者：
Rasmussen,DD;Yen,SS
采用体外灌流系统，观察孕酮(P4)和20α-羟孕酮(20α-OHP)对去卵巢-17-β诱导的成年大鼠下丘脑组织促性腺激素释放激素释放的影响。脉冲给予P4不仅可刺激下丘脑内侧基底区-下丘脑前-视前区复合体(MBH-AHPOA)的GnRH释放，也可单独刺激MBH的释放。20α-OHP也增加了促性腺激素释放激素的释放。这些结果提示，体内循环P4或20α-OHP水平的升高可能通过直接刺激促性腺激素释放激素来调节排卵前黄体生成素高峰的发生时间或幅度。
An in vitro perifusion system was used to investigate the effect of progesterone (P 4) and 20α-hydroxyprogesterone (20α-OHP) on the release of GnRH from isolated hypothalamic tissue of the adult ovariectomized estradiol-17β primed rat. Pulse delivery of P 4 stimulated GnRH release not only from the isolated mediobasal hypothalamus-anterior hypothalamus-preoptic area (MBH-AHPOA) complex but also from the MBH alone. Release of GnRH from the MBH was also increased by 20α-OHP. These results suggest that the in vivo increase of circulating P 4 or 20α-OHP associated with the initiation of the preovulatory LH surge may play a role in regulating the timing or amplitude of this surge by directly stimulating the release of GnRH from the MBH.