Highly efficient and versatile synthesis of lactams and N-heterocycles via Al(OTf)3-catalyzed cascade cyclization and ionic hydrogenation reactions.
Highly efficient and versatile synthesis of lactams and N-heterocycles via Al(OTf)3-catalyzed cascade cyclization and ionic hydrogenation reactions.
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DOI：
10.1021/ol403173x
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发表时间：
2014-01
期刊：
影响因子：
5.2
通讯作者：
J. Qi;Chenbin Sun;Yulin Tian;Xiaojian Wang;Gang Li;Qiong Xiao;D. Yin
中科院分区：
文献类型：
--
作者：
J. Qi;Chenbin Sun;Yulin Tian;Xiaojian Wang;Gang Li;Qiong Xiao;D. Yin
描述了一种有效且通用的 N-取代内酰胺合成方法的发现和开发。通过 Al(OTf)3 催化的级联环化和相应氮取代酮酰胺的离子氢化反应，以良好的产率形成吡咯烷酮、哌啶酮和结构相关的杂环。
The discovery and development of an efficient and versatile method for the synthesis of N-substituted lactams is described. Pyrrolindinones, piperidones, and structurally related heterocycles were formed by Al(OTf)3-catalyzed cascade cyclization and ionic hydrogenation reactions of corresponding nitrogen substituted ketoamides in good yields.