Femtogram detection and quantitation of residues using laser ionization orthogonal time-of-flight mass spectrometry.
Femtogram detection and quantitation of residues using laser ionization orthogonal time-of-flight mass spectrometry.
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DOI：
10.1021/ac901615k
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发表时间：
2009-09
影响因子：
7.4
通讯作者：
Quan Yu;Zhi-jian Cao;Lingfeng Li;Bin Yan;W. Hang;Jian He;Benli Huang
中科院分区：
文献类型：
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作者：
Quan Yu;Zhi-jian Cao;Lingfeng Li;Bin Yan;W. Hang;Jian He;Benli Huang
利用自行研制的高强度激光电离正交飞行时间质谱仪(Li-O-TOFMS)对混合盐溶液蒸发制备的残留物进行了元素分析。首先对残基的形状和元素分布进行了表征。在TOFMS检测中，可以在光谱中观察到残留物中的所有金属元素。不同元素的相对灵敏度系数均在1个数量级以内，符合半定量分析标准。通过计算单个激光烧蚀区域的单个质量，大多数金属元素的绝对检测下限达到7×10(-15)g。结果表明，Li-O-TOFMS能够进行超痕量元素的定性和定量，其绝对检出限和绝对定量限在飞秒能谱水平。
A newly developed high irradiance laser ionization orthogonal time-of-flight mass spectrometer (LI-O-TOFMS) was employed for the elemental analysis of residues, which were prepared by evaporating mixed salt solutions. The residues were first characterized in terms of shape and elemental distribution. In TOFMS detection, all of the metal elements in the residue can be observed in the spectra. Relative sensitivity coefficients for different elements were within 1 order of magnitude, which meets semiquantitative analysis criteria. By calculating the individual masses from the ablated area due to a single laser shot, the absolute detection limit reached 7 x 10(-15) g for most metal elements. The results indicate that LI-O-TOFMS is capable of performing ultratrace elemental qualification and quantification, with an absolute limit of detection and an absolute limit of quantitation at the femtogram level.