Somatostatin inhibits the isoproterenol-stimulated adenylate cyclase in the intermediate lobe of the male rat pituitary gland.
Somatostatin inhibits the isoproterenol-stimulated adenylate cyclase in the intermediate lobe of the male rat pituitary gland.
复制标题
生长抑素抑制雄性大鼠垂体中叶中异丙肾上腺素刺激的腺苷酸环化酶。
作者：
F. Corrêa;J. Saavedra
生长抑素-14抑制雄性大鼠垂体中叶无细胞匀浆中异丙肾上腺素刺激的腺苷酸环化酶，Ki为7.25 +/- 0.31 × 10（-7）M。生长抑素-28被发现是一种部分激动剂。其他神经肽（甲硫氨酸和亮氨酸脑啡肽、β-内啡肽、α-黑素细胞刺激激素、ACTH、神经降压素、P物质、血管活性肠多肽和加压素）无影响。我们的研究结果表明，垂体和/或脑生长抑素在垂体中叶的生理调节中的作用，以及生长抑素和儿茶酚胺之间的相互作用对中叶腺苷酸环化酶的调节的可能性。
Somatostatin-14 inhibited the isoproterenol-stimulated adenylate cyclase in cell-free homogenates of pituitary intermediate lobe of the male rat with a Ki of 7.25 +/- 0.31 X 10(-7) M. Somatostatin-28 was found to be a partial agonist. Other neuropeptides (met- and leu-enkephalin, beta-endorphin, alpha-melanocyte-stimulating hormone, ACTH, neurotensin, substance P, vasoactive intestinal polypeptide, and vasopressin) were without effect. Our results suggest a role for pituitary and/or brain somatostatin in the physiological regulation of the intermediate pituitary lobe, and the possibility of an interaction between somatostatins and catecholamines on the regulation of intermediate lobe adenylate cyclase.