Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease.
Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease.
复制标题
免疫母细胞性淋巴结病。
DOI：
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发表时间：
1975
影响因子：
158.5
通讯作者：
B. Tindle
中科院分区：
文献类型：
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作者：
R. Lukes;B. Tindle
免疫母细胞性淋巴结病虽然与霍奇金氏病相似，但它是一种明显的b细胞系统高免疫疾病。在32例中，其形态学特征为三要素：树突状小血管增生；显著的免疫母细胞增生；以及无定形的亲酸性间隙物质。临床表现为发热、出汗、体重减轻，偶有皮疹、全身性淋巴结病，常伴有肝脾肿大。有一致的多克隆性高球蛋白血症和经常溶血性贫血。病程通常是进行性的，18例死亡病例的中位生存期为15个月。在治疗前的活组织检查和12例可用的尸检病例中的10例中，细胞增殖在形态学上显示为良性。在三个病例的过程演变成免疫母细胞淋巴瘤，免疫母细胞肉瘤。基本过程似乎是b细胞系统的非肿瘤性超免疫增殖，涉及淋巴细胞向免疫母细胞和浆细胞转化的夸张，这可能是由对治疗剂的超敏反应引起的。
Immunoblastic lymphadenopathy, although it resembles Hodgkin's disease, is a distinct, hyperimmune disorder apparently of the B-cell system. In 32 cases, it was characterized by a morphologic triad: proliferation of arborizing small vessels; prominent immunoblastic proliferations; and amorphous acidophilic interstitial material. Clinically, it is manifested by fever, sweats, weight loss, occasionally a rash, generalized lymphadenopathy and often hepatosplenomegaly. There is a consistent polyclonal hyperglobulinemia and often hemolytic anemia. The course of the disease is usually progressive, with a median survival of 15 months in 18 fatal cases. The cellular proliferation appears benign morphologically in the pretherapy biopsies and in 10 of 12 available autopsy cases. In three cases the process evolved into a lymphoma of immunoblasts, immunoblastic sarcoma. The basic process appears to be a non-neoplastic hyperimmune proliferation of the B-cell system involving an exaggeration of lymphocyte transformation to immunoblasts and plasma cells that may be triggered by a hypersensitivity reaction to therapeutic agents.