EFFECT OF ADVANCING GESTATIONAL-AGE ON THE FREQUENCY OF FETAL DUCTAL CONSTRICTION IN ASSOCIATION WITH MATERNAL INDOMETHACIN USE
EFFECT OF ADVANCING GESTATIONAL-AGE ON THE FREQUENCY OF FETAL DUCTAL CONSTRICTION IN ASSOCIATION WITH MATERNAL INDOMETHACIN USE
复制标题
DOI：
10.1016/s0002-9378(11)90763-7
复制
发表时间：
1993-05-01
影响因子：
9.8
通讯作者：
MOISE, KJ
中科院分区：
文献类型：
--
作者：
MOISE, KJ
目的：本研究的目的是确定吲哚美辛是否与人类胎儿动脉导管缩窄的发病率增加，提前gestational age.Study设计：44例早产或羊水过多患者用吲哚美辛（25毫克口服每6小时）进行胎儿超声心动图进行回顾性分析。Fisher精确检验，Kaplan-Meier生存分析，对数秩技术，P < 0.05的值被认为是统计学显着。结果：导管收缩的频率是相似的单胎和多胎妊娠的胎儿。孕32周时，当妊娠合并症的发生率接近50%时，子宫收缩明显增加。
OBJECTIVE: The objective of this study was to determine whether indomethacin is associated with an increased incidence of constriction of the human fetal ductus arteriosus with advancing gestational age.STUDY DESIGN: A retrospective analysis of fetal echocardiograms performed in 44 patients with premature labor or hydramnios treated with indomethacin (25 mg orally every 6 hours) was undertaken. Fisher's exact test, Kaplan-Meier survival analysis, and log-rank techniques were used; a value of p < 0.05 was considered statistically significant.RESULTS: The frequency of ductal constriction was similar for fetuses of singleton and multiple gestations. A dramatic increase in constriction was noted at 32 weeks' gestation when the rate of compromise approached 50%.CONCLUSIONS: The use of indomethacin should be restricted to gestational ages of