Effect of exercise on age-related muscle atrophy
Effect of exercise on age-related muscle atrophy
复制标题
运动对年龄相关性肌肉萎缩的影响
DOI：
10.1016/0197-4580(93)90118-u
复制
发表时间：
1993
影响因子：
4.2
通讯作者：
S. Taguchi
中科院分区：
文献类型：
--
作者：
A. Ishihara;S. Taguchi
55周龄雄性Wistar大鼠自愿在跑轮上运动10周。记录比目鱼肌(SOL)和胫骨前肌(TA)慢抽动肌(SOL)和快抽动肌(TA)的纤维数目和横截面积，并与20周龄大鼠和年龄匹配的未运动大鼠进行比较。肌肉纤维分为快抽动氧化糖酵解(FOG)、快抽动糖酵解(FG)或慢抽动氧化(SO)。在SOL和TA内注射辣根过氧化物酶逆行标记神经元后，用显微分光光度法检测脊髓运动神经元的氧化酶活性。65周龄SOL中雾状纤维较20周龄少，TA中FG纤维较少。65周龄TA内雾纤维和FG纤维的横截面积低于20周龄。运动可防止TA内雾状纤维的萎缩。在SOL和TA中运动神经元的数量或氧化酶活性没有年龄或运动相关的差异。这些发现表明，运动可以通过恢复降低的代谢能力和抑制神经肌肉接头的退化来防止雾纤维的萎缩。
Fifty-five-week-old male Wistar rats exercised voluntarily in running wheels for 10 weeks. The number and cross-sectional area of fibers in the slow-twitch soleus (SOL) and fast-twitch tibialis anterior (TA) muscles were recorded and compared with those of 20-week-old rats, and of age-matched rats not exercised. Muscle fibers were classified as fast-twitch oxidative glycolytic (FOG), fast-twitch glycolytic (FG), or slow-twitch oxidative (SO). After injection of horseradish peroxidase into the SOL and TA for retrograde neuronal labeling, oxidative enzyme activity of labeled motoneurons in the spinal cord was measured by microspectrophotometry. There were fewer FOG fibers in the SOL, and fewer FG fibers in the TA, at 65 weeks than at 20 weeks of age. The cross-sectional area of FOG and FG fibers in the TA was lower at 65 weeks than at 20 weeks of age. Exercise prevented the atrophy of FOG fibers in the TA. There were no age- or exercise-related differences in the number or oxidative enzyme activity of motoneurons in the SOL or the TA. These findings suggest that exercise can prevent the atrophy of FOG fibers by restoring their decreased metabolic capacity, and by inhibiting the degeneration of neuromuscular junctions.