Standardization of lipid, lipoprotein, and apolipoprotein measurements.
Standardization of lipid, lipoprotein, and apolipoprotein measurements.
复制标题
脂质、脂蛋白和载脂蛋白测量的标准化。
作者：
G. Cooper;G. Myers;S. J. Smith;E. Sampson
准确的实验室测量血清胆固醇已成为国家公共卫生的优先事项。国家能力验证调查表明，胆固醇检测的实验室不准确性比精确度更严重。与精密度一样，准确度也是多个分析前和分析变异源的函数。控制分析前的变异源有助于最大限度地减少变异源，例如人体内的生物学、行为和临床差异，以及样本收集、处理和运输引起的变异。分析变异来源的标准化有助于实现并保持理想的分析性能、准确的报告以及对报告的胆固醇结果的正确解释。当人们解释单个结果或来自单个人的一系列结果时，脂蛋白及其成分的人内总变异是最重要的。如果要获得人体内总胆固醇的准确值并最大限度地减少分析前的变异来源，则需要同一个人的多个样本的平均值。对某些仪器系统中的变异分析源进行标准化需要通过使用“新鲜”患者标本来标准化结果。
Accurate laboratory measurement of serum cholesterol has become a national public health priority. National proficiency testing surveys indicate that laboratory inaccuracy in cholesterol testing is more of a problem than precision. Like precision, accuracy is a function of multiple pre-analytical and analytical sources of variation. Controlling pre-analytical sources of variation helps minimize such sources of variation as intraperson biological, behavioral, and clinical differences, and variations caused by sample collection, handling, and shipping. Standardization of analytical sources of variation helps to achieve and maintain desirable analytical performance, accurate reporting, and correct interpretation of a reported cholesterol result. The intraperson total variation in lipoproteins and their constituents is of primary interest when one is interpreting a single result or a series of results from a single person. The mean of multiple specimens from the same person is required if one is to obtain an accurate value for intraperson total cholesterol and minimize pre-analytical sources of variation. Standardizing analytical sources of variation in some instrument systems requires standardizing results by using "fresh" patients' specimens.