The use of biochemical markers of bone turnover in osteoporosis
The use of biochemical markers of bone turnover in osteoporosis
复制标题
DOI：
10.1007/s001980070002
复制
发表时间：
2000-01-01
影响因子：
4
通讯作者：
Stepan, J
中科院分区：
文献类型：
--
作者：
Delmas, PD;Eastell, R;Stepan, J
在过去的20年里，骨转换的生化标志物已经开发出来，这些标志物对骨组织的特异性比传统标志物更高。因此，一些研究表明，这些新的标志物比传统的检测骨转换率异常更敏感。它们已被广泛用于临床研究和新疗法的临床试验中，作为治疗有效性的次要终点。大多数的兴趣已经致力于他们在绝经后骨质疏松症，一个条件的特点是微妙的骨代谢的变化，不能很容易地检测到的骨转换的传统标志物的使用。然而，它们在个体患者管理中的临床使用尚未明确，并且是一个有争议的问题。由于澄清这一问题至关重要，国际骨质疏松症基金会科学顾问委员会委托一个专家委员会总结现有数据并提出建议。以下文件包括：
Biochemical markers of bone turnover have been developed over the past 20 years that are more speciŽc for bone tissue than conventional ones. As a result, several studies have shown that these new markers are more sensitive than conventional ones for detecting abnormalities of bone turnover rate. They have been widely used in clinical research and in clinical trials of new therapies as secondary endpoints of treatment efŽcacy. Most of the interest has been devoted to their use in postmenopausal osteoporosis, a condition characterized by subtle modiŽcations of bone metabolism that cannot readily be detected by conventional markers of bone turnover. However, their clinical use in the management of the individual patient has not been clearly deŽned and is a matter of debate. Because of the crucial importance of clarifying this issue, the Committee of ScientiŽc Advisors of the International Osteoporosis Foundation commissioned an expert committee to summarize the available data and to make recommendations. The following paper includes: