Effects of neuropeptide Y on cochlear blood flow in guinea pigs.
Effects of neuropeptide Y on cochlear blood flow in guinea pigs.
复制标题
神经肽 Y 对豚鼠耳蜗血流的影响。
作者：
M. Itou;K. Ogawa;Y. Inoue;M. Sato;J. Kanzaki
本研究旨在探讨神经肽Y(NPY)对色素豚鼠耳蜗血流量(CBF)的影响。分别采用全身灌流或淋巴外局部灌流的方式给予NPY加或不加去甲肾上腺素(NA)，并用激光多普勒血流仪测定脑血流量。NPY联合NA全身给药和周围淋巴管给药较单用NA或NPY更能延长CBF增加和恢复的时间。NPY引起的CBF持续减少可能在应激性感音神经性耳聋(如突聋)的发病机制中起重要作用。
The aim of this study was to clarify the effects of neuropeptide Y (NPY) on cochlear blood flow (CBF) in pigmented guinea pigs. NPY was administered with or without noradrenaline (NA) by systemic perfusion or perilymphatic local perfusion, and CBF was measured using a laser Doppler flowmeter. The systemic and perilymphatic administrations of NPY with NA induced greater prolongation of the increase in and recovery of CBF than the administration of NA or NPY alone. Continuous reduction in CBF induced by NPY may play an important role in the pathogenesis of stress-induced sensorineural hearing losses, such as sudden deafness.
影响因子：
20.1
作者：
Zukowska-Grojec, Z;Karwatowska-Prokopczuk, E;Grant, DS
通讯作者：
Grant, DS