Antifatigue activity of ethanolic extract of Ocimum sanctum in rats.
Antifatigue activity of ethanolic extract of Ocimum sanctum in rats.
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DOI：
10.3923/rjmp.2012.37.46
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Khanum, F.
中科院分区：
文献类型：
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作者：
Prasad, M. P. V.;Farhath Khanum, Farhath Khanum;Khanum, F.
圣罗勒以其药用特性而闻名，自吠陀时代以来在印度也被认为是神圣的。研究了圣罗勒 70% 酒精提取物的水悬浮液的抗疲劳活性。每隔一天对大鼠进行负重强迫游泳测试（WFST），持续两周。 O. sainttum，剂量为 150、300 和 450 mg kg-1 b.wt。每天对大鼠给药。游泳时间、体重变化、脂质过氧化、乳酸（LA）、糖原和血液生化参数，即血红蛋白（Hb%）、血尿素氮（BUN）和肌酸激酶（CK）被评估为身体疲劳的生物标志物。研究发现，与对照组运动组相比，O. sainttum 治疗可降低肝脏和肌肉组织中的丙二醛 (MDA) 和乳酸水平 (p
Ocimum sanctum L. is known for its medicinal properties and also has been considered sacred in India since Vedic times. The aqueous suspension of 70% alcoholic extract of Ocimum sanctum L. was investigated for antifatigue activity. Rats were subjected to Weight-loaded Forced Swim Test (WFST) every alternate day for 2 weeks. O. sanctum at a dosage of 150, 300 and 450 mg kg-1 b.wt. was administrated to rats every day. Swimming time, change in body weight, lipid peroxidation, Lactic Acid (LA), glycogen and blood biochemical parameters namely heamoglobin (Hb%), Blood Urea Nitrogen (BUN) and Creatine Kinase (CK) were evaluated as biomarkers of physical fatigue. The O. sanctum treatment was found to lower malondialdehyde (MDA) and lactic acid levels in liver and muscle tissues compared with control exercise group (p