Decrease of serotonin transporters in blood platelets after epileptic seizures
Decrease of serotonin transporters in blood platelets after epileptic seizures
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DOI：
10.1007/s11064-005-2676-2
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发表时间：
2005-04-01
影响因子：
4.4
通讯作者：
Albano, C
中科院分区：
文献类型：
--
作者：
Cupello, A;Favale, E;Albano, C
用[H-3]-帕罗西汀结合法研究了癫痫患者和正常对照者血小板中5-羟色胺转运体（SERT）的活性。两种情况下的平均K-D和B-Max无差异。然而，一个显着的减少，发现在血小板膜中的5-羟色胺转运体密度从患者经历了癫痫发作不到4天前。这种情况可能表明对癫痫发作的稳态反应。
Serotonin transporter (SERT) was studied by [H-3]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average K-D and B-Max were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.