Exposure to CB-153 and p,p′-DDE and male reproductive function
Exposure to CB-153 and p,p′-DDE and male reproductive function
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DOI：
10.1093/humrep/deh362
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发表时间：
2004-09-01
影响因子：
6.1
通讯作者：
Hagmar, L
中科院分区：
文献类型：
--
作者：
Rignell-Hydbom, A;Rylander, L;Hagmar, L
背景技术背景：在过去的几十年里，人们一直担心，接触内分泌干扰物，如持久性有机氯污染物（持久性有机氯污染物），可能会损害男性生殖功能。为研究暴露于2，2 '4，4' 5，5 '-六氯联苯（CB-153）和1，1-二氯-2，2-双（对氯苯基）-乙烯（p，p'-DDE）是否会影响精液数量和质量以及生殖激素，对195名年龄在24-65岁的瑞典渔民进行了调查。方法：男性提供精液样本，在移动的实验室进行分析。采集血液样本和与生活方式、病史和生殖史相关的信息。研究结果：受试者的中位CB-153血清水平为193 ng/g脂质（范围39-1460），中位p，p '-DDE血清水平为240 ng/g脂质（范围334-2251）。当CB-153被分为五分位数时，与最低五分位数的受试者相比，最高浓度（>328 ng/g脂质）的五分位数的受试者往往具有降低的精子活力（
BACKGROUND: During the last decades, there has been concern that exposure to endocrine disruptors, such as persistent organochlorine pollutants (POPs), may contribute to an impairment of male reproductive function. To investigate whether exposure to 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) affects semen quantity and quality and reproductive hormones, 195 Swedish fishermen, aged 24-65 years, were investigated. METHODS: The men provided semen samples which were analysed in a mobile laboratory unit. Blood samples and information relating to lifestyle, medical and reproductive history were obtained. RESULTS: The subjects had a median CB-153 serum level of 193 ng/g lipid (range 39-1460) and a median p,p'-DDE serum level of 240 ng/g lipid (range 334-2251). When CB-153 was categorized into quintiles, the subjects in the quintile with the highest concentration (>328 ng/g lipid), tended to have decreased sperm motility compared with the subjects in the lowest quintile (