Regulation of interleukin 2 receptors on T cells from multiple sclerosis patients.
Regulation of interleukin 2 receptors on T cells from multiple sclerosis patients.
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多发性硬化症患者 T 细胞上白细胞介素 2 受体的调节。
DOI：
10.1073/pnas.83.8.2637
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发表时间：
1986
影响因子：
11.1
通讯作者：
Koprowski,H
中科院分区：
文献类型：
--
作者：
DeFreitas,EC;Sandberg-Wollheim,M;Schonely,K;Boufal,M;Koprowski,H
白细胞介素2（IL-2）受体在静息T淋巴细胞上不存在，并由抗原和促有丝分裂刺激诱导。在有限的时间（8-12天）后，尽管存在受体饱和浓度的IL-2，但正常T细胞上的这些受体被下调。我们在这里报告，抗原和丝裂原诱导的T细胞系和克隆从多发性硬化症患者的外周血和脑脊液中获得的IL-2受体的表达时间延长。这种表达与对IL-2的增殖作用的延长的反应性一致。此外，Leu 3+，IL-2受体阳性T细胞克隆从多发性硬化症患者的脑脊液已建立和维持超过1年没有IL-2。该克隆具有经人嗜T淋巴细胞病毒I型转化或感染的T细胞的某些形态学和组织化学特性。
Receptors for interleukin 2 (IL-2) are absent on resting T lymphocytes and are induced by antigenic and mitogenic stimulation. After a limited time (8-12 days), these receptors on normal T cells are down-regulated despite the presence of receptor-saturating concentrations of IL-2. We report here that both antigen- and mitogen-induced T-cell lines and clones obtained from peripheral blood and cerebrospinal fluid of multiple sclerosis patients show prolonged expression of IL-2 receptors. This expression is coincident with a prolonged responsiveness to the proliferative effects of IL-2. In addition, Leu 3+, IL-2 receptor-positive T-cell clone from the cerebrospinal fluid of a multiple sclerosis patient has been established and maintained for more than 1 year without IL-2. This clone has some morphologic and histochemical properties of T cells transformed or infected by human T-lymphotropic virus type I.