Wavelength and vulnerability to atrial fibrillation: Insights from a computer model of human atria
Wavelength and vulnerability to atrial fibrillation: Insights from a computer model of human atria
复制标题
DOI：
10.1016/j.eupc.2005.03.017
复制
发表时间：
2005-09-01
期刊：
影响因子：
6.1
通讯作者：
Kappenberger, L
中科院分区：
文献类型：
--
作者：
Jacquemet, V;Virag, N;Kappenberger, L
目的解释心房颤动（AF）发生和持续的临界心脏波长概念相关的矛盾结果。方法使用基于生物物理的计算机模型：（1）研究了在多重重入小波存在下波长与AF永存的关系，（2）评估在不同致发光底物存在下用于波长估计的不同现有方法的性能，以及（3）记录不应度的不均匀性或母转子的存在对波长估计的影响。结果模拟证实波长必须低于维持AF的临界值，当永存机制依赖于多重入小波时。波长的估计值是不相同的所有e的方法测试，部分取决于AF dynamic.Conclusion的时空组织的性质的基本小波动力学的先验信息是需要正确的解释心脏波长估计由目前的临床方法。(c)2005年欧洲心脏病学会。由爱思唯尔有限公司出版。保留所有权利。
Aim To explain the contradictory results related to the concept of critical cardiac wavelength in the initiation and perpetuation of atria[ fibrillation (AF).Methods A biophysically based computer model was used to: (1) study the relationship between wavelength and AF perpetuation in the presence of multiple re-entrant wavelets, (2) evaluate the performance of different existing methods for wavelength estimation in the presence of different arrhythmogenic substrates, and (3) document the impact of either heterogeneities in refractoriness or the presence of a mother rotor on wavelength estimation.Results The simulations confirmed that the wavelength must be below a critical value for AF to be sustained, when the perpetuation mechanism relies on multiple re-entrant wavelets. The estimated value of wavelength was not the same for all e methods tested and depended in part on the nature of the spatio-temporal organization of the AF dynamics.Conclusion A priori information about the underlying wavelet dynamics is needed for a correct interpretation of the cardiac wavelength as estimated by the current clinical methods. (c) 2005 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.