Lipoxygenases: Occurrence, functions and catalysis
Lipoxygenases: Occurrence, functions and catalysis
复制标题
DOI：
10.1016/j.jplph.2005.11.006
复制
发表时间：
2006-02-01
影响因子：
4.3
通讯作者：
Feussner, N
中科院分区：
文献类型：
--
作者：
Liavonchanka, A;Feussner, N
脂质过氧化在所有生物系统中都是常见的，出现在发育和环境调节的过程中。产品是氢过氧多不饱和脂肪酸和代谢物，这些代谢物统称为氧脂。它们可能起源于化学氧化，也可能是通过各种酶的作用而合成的，例如脂氧合酶(Lox)。许多产品包括茉莉酸酯等信号化合物、叶醛或二乙烯基醚等抗微生物和抗真菌化合物，以及包括叶醇在内的植物特有的挥发物混合物。许多氧化脂质代谢关键酶的克隆，以及反向遗传方法和代谢谱的分析，揭示了对氧化脂质功能的新见解、新的反应和关于酶机制的第一次暗示。从特定LOX形式的功能、底物和产物特异性的新模型的开发等方面对这些方面进行了综述。(C)2005年爱思唯尔股份有限公司。版权所有。
Lipid peroxidation is common to all biological systems, both appearing in developmentally and environmentally regulated processes. Products are hydroperoxy polyunsaturated fatty acids and metabolites derived there from collectively named oxylipins. They may either originate from chemical oxidation or are synthesized by the action of various enzymes, such as lipoxygenases (LOXes). Signalling compounds such as jasmonates, antimicrobial and antifungal compounds such as leaf aldehydes or divinyl ethers, and a plant-specific blend of volatiles including leaf alcohols are among the numerous products. Cloning of many LOXes and other key enzymes metabolizing oxylipins, as well as analyses by reverse genetic approaches and metabolic profiling revealed new insights on oxylipin functions, new reactions and the first hints on enzyme mechanisms. These aspects are reviewed with respect to function of specific LOX forms and on the development of new models on their substrate and product specificity. (c) 2005 Elsevier GmbH. All rights reserved.