Oncological Safety of Lipofilling in Patients with Breast Cancer: A Meta-analysis and Update on Clinical Practice
Oncological Safety of Lipofilling in Patients with Breast Cancer: A Meta-analysis and Update on Clinical Practice
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乳腺癌患者脂肪填充的肿瘤学安全性：临床实践的荟萃分析和更新
DOI：
10.21873/anticanres.10999
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发表时间：
2016
影响因子：
2
通讯作者：
K. Mokbel
中科院分区：
文献类型：
--
作者：
U. Wazir;H. Chehade;Hannah Headon;M. Oteifa;A. Kasem;K. Mokbel
背景：脂肪填充是乳房切除术和保乳手术（BCS）后乳房再造的一种越来越流行的技术。然而，人们仍然担心其肿瘤安全性及其对癌症复发的影响。材料和方法：进行系统的文献综述和荟萃分析。分别对接受乳房切除术或BCS的患者进行研究，以了解添加脂肪填充是否对局部复发率有显著影响。结果：分析中使用了11项研究，共计2，382例患者。对于接受乳房切除术（平均随访=36.2个月，范围=12-90个月）或BCS（平均随访=30.2个月，范围=12-60个月）的患者，未发现添加脂肪填充对局部复发率有显著影响。结论：这项荟萃分析表明，脂肪填充术是一种肿瘤安全的程序，可纳入乳房切除术或乳腺癌BCS后的乳房再造。但是，建议进行仔细的肿瘤学随访。在未来，需要更充分的动力对照临床试验，以充分了解脂肪填充后的长期结果。
BACKGROUND: Lipofilling is an increasingly popular technique for breast reconstruction following both mastectomy and breast-conserving surgery (BCS). However, concerns remain over its oncological safety and its effect on cancer recurrence. MATERIALS AND METHODS: A systematic literature review and meta-analysis was carried out. Patients who had undergone mastectomy or BCS were investigated separately in order to find out whether the addition of lipofilling had a significant effect on locoregional recurrence rate. RESULTS: Eleven studies were used in the analysis, yielding a total of 2,382 patients. For patients undergoing mastectomy (mean follow-up=36.2 months, range=12-90 months) or BCS (mean follow-up=30.2 months, range=12-60 months), the addition of lipofilling was not found to significantly affect the locoregional recurrence rate. CONCLUSION: This meta-analysis demonstrates that lipofilling is an oncologically safe procedure to be incorporated into breast reconstruction following either mastectomy or BCS for breast cancer. However, a careful oncological follow-up is recommended. In the future, more adequately powered controlled clinical trials are needed in order to fully understand long-term outcomes after lipofilling.