Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation
Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation
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DOI：
10.1126/science.1081846
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发表时间：
2003-04-18
期刊：
影响因子：
56.9
通讯作者：
Amon, A
中科院分区：
文献类型：
--
作者：
Lee, BH;Amon, A
减数分裂是一种特殊的细胞分裂，其中两个染色体分离阶段跟随单个DNA复制阶段。芽殖酵母Polo样激酶Cdc5被发现有助于建立减数分裂I染色体分离程序。Cdc5需要磷酸化和去除染色体上的减数分裂粘连蛋白。此外，在没有CDC5的着丝粒是双向的减数分裂I，和Mam 1，一个蛋白质的共同取向，未能与着丝粒。因此，姐妹动粒共取向和染色体分离减数分裂I耦合通过其依赖于CDC 5。
Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.