INCREASED CONCENTRATION OF CALCITONIN-GENE-RELATED PEPTIDE IN CEREBROSPINAL-FLUID OF DEPRESSED-PATIENTS - A POSSIBLE TRAIT MARKER OF MAJOR DEPRESSIVE DISORDER
INCREASED CONCENTRATION OF CALCITONIN-GENE-RELATED PEPTIDE IN CEREBROSPINAL-FLUID OF DEPRESSED-PATIENTS - A POSSIBLE TRAIT MARKER OF MAJOR DEPRESSIVE DISORDER
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DOI：
10.1016/0304-3940(94)90782-x
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发表时间：
1994-12-05
影响因子：
2.5
通讯作者：
THEODORSSON, E
中科院分区：
文献类型：
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作者：
MATHE, AA;AGREN, H;THEODORSSON, E
在受控条件下从患有重性抑郁症（n = 63）或精神分裂症（n = 28）的受试者和健康对照（n = 20）收集脑脊液（CSF）。Sep-pak提取后，通过放射免疫测定法测定样品等分试样中的降钙素基因相关肽免疫反应性（CGRP-LI）。抑郁症组CSF中CGRP-LI浓度明显高于精神分裂症组和对照组（P <0.001）。后两组间CGRP-LI差异无统计学意义。CGRP-LI与研究的任何技术（例如储存条件）或患者（人口统计学、生物化学或临床）变量无关。鉴于CGRP在脑内的离散性分布和特异性作用，以及上述结果，我们推测CSF中CGRP-LI增高可能是抑郁症的一个特征性标志。无论机制（改变合成/释放/代谢的大脑或改变命运的CSF）导致CSF CGRP-LI升高，一个可能的疾病特征标记的识别应有助于早期诊断的抑郁症和识别的家庭成员的风险，并可能有助于其他疾病的情感障碍的鉴别诊断。
Cerebrospinal fluid (CSF) was collected under controlled conditions from subjects suffering from major depression (n = 63) or schizophrenia (n = 28) and from healthy controls (n = 20). Following Sep-pak extraction, calcitonin gene-related peptide immunoreactivity (CGRP-LI) was determined by radioimmunoassay in sample aliquots. CGRP-LI concentrations in CSF were increased in the depressed patients compared to the schizophrenic and control subjects (P < 0.001). No CGRP-LI differences were found between the latter two groups. CGRP-LI did not correlate to any of the technical (e.g. storage conditions) or patient (demographic, biochemical, or clinical) variables investigated. In view of the CGRP's discrete distribution and specific effects in brain and the above results, we hypothesize that increased CSF CGRP-LI might be a trait marker of major depression. Regardless of the mechanisms (altered synthesis/release/metabolism in brain or changed fate in CSF) leading to elevated CSF CGRP-LI, the identification of a possible disease trait marker should contribute to the early diagnosis of major depression and identification of family members at risk and may help in differential diagnosis in other disorders with affective symptomatology.