Lateral parabrachial lesions impair taste aversion learning induced by blood-borne visceral stimuli
Lateral parabrachial lesions impair taste aversion learning induced by blood-borne visceral stimuli
复制标题
DOI：
10.1016/s0091-3057(01)00494-4
复制
发表时间：
2001-05-01
影响因子：
3.6
通讯作者：
Puerto, A
中科院分区：
文献类型：
--
作者：
Cubero, I;Lopez, M;Puerto, A
侧臂旁区（LPB）是后脑区（AP）的主要中继，在处理内脏信息中起作用，因此在味觉厌恶学习（TAL）中具有潜在的重要性。本研究使用病变方法来解决LPB功能相关性是否取决于TAL中作为内脏刺激的毒素的特征。此外，我们探讨了LPB参与TAL是否仅限于AP检测到的毒性事件，或者它是否具有更广泛的作用。结果显示，经血源性ap依赖性厌恶刺激（腹腔注射甲基东莨菪碱）和ap非依赖性刺激（腹腔注射乙醇）诱导的lbp损伤动物获得TAL的过程被破坏，但当经迷走神经加工的高渗氯化钠作为胃内厌恶刺激时，仍明显产生强烈的厌恶。这些发现表明LPB在血源性毒素（如甲基东莨菪碱或乙醇）诱导的TAL中起关键作用，但对于迷走神经介导的刺激（如氯化钠）则不是必需的。目前的结果是在假设持有可分离的和独立的神经系统基础TAL的背景下讨论。(C) 2001爱思唯尔科学公司版权所有。
The lateral parabrachial area (LPB), main relay from the area postrema (AP), plays a role in processing visceral information and is thus of potential importance in taste aversion learning (TAL). This study used a lesion approach to address whether LPB functional relevance depends upon the features of toxins that serves as visceral stimuli in TAL. In addition, we explored whether LPB involvement in TAL is restricted to those toxic events detected by the AP or whether it has a more general role. Results showed that LPB-lesioned animals were disrupted in acquiring a TAL induced by blood-borne AP-dependent aversive stimuli (intraperitoneal methylscopolamine) and by AP-independent stimulus (intraperitoneal ethanol), but still, clearly developed strong aversions when intragastric hypertonic sodium chloride, a vagally processed aversive stimulus, served as the aversive stimulus. These findings suggest that the LPB plays a critical role in TAL induced by blood-borne toxins, such as methylscopolamine or ethanol, but is not necessary for vagally mediated stimulus, such as sodium chloride. The present results are discussed in the context of the hypothesis holding separable and independent neural systems underlying TAL. (C) 2001 Elsevier Science Inc. All rights reserved.