Permeation of drug and swelling agent through polymeric membranes
Permeation of drug and swelling agent through polymeric membranes
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药物和溶胀剂通过聚合物膜的渗透
DOI：
10.1002/aic.690461207
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发表时间：
2000
期刊：
影响因子：
3.7
通讯作者：
Hsiu
中科院分区：
文献类型：
--
作者：
Da;Ching;C. Chu;Hsiu
本文从理论和实验两方面研究了药物（苯并咪唑）和溶胀剂（乙醇）通过聚（乙烯-醋酸乙烯酯）和聚氨酯聚合物膜的渗透。基于Flory-Huggins和Yasuda理论，通过将渗透扩散系数表示为溶胀剂活性的幂，来描述溶胀对渗透扩散系数的影响。实验结果表明，领先的顺序项（第一顺序的活动）是准确的，足以描述苯并呋喃和乙醇在聚（乙烯-共-醋酸乙烯酯）和聚氨酯膜的扩散系数。渗透扩散系数对溶胀剂活性的线性依赖性进一步用于分析受溶胀梯度影响的膜中的药物扩散。随着苯并咪唑和乙醇扩散系数对乙醇活性的依赖性的知识，可以计算乙醇穿过膜的活性分布，然后可以预测苯并咪唑的有效扩散系数。进行实验，以确定相应于不同的溶胀梯度的有效苯并咪唑扩散系数的变化与计算结果吻合良好。
The permeation of drug (benzocaine) and swelling agent (ethanol) through the polymeric [poly(ethylene-co-vinylacetate) and polyurethane] membranes was investigated theoretically and experimentally. Based on the Flory-Huggins and Yasuda theories, the swelling effect on permeant diffusivity was described by expressing the permeant diffusivity in powers of the activity of the swelling agent. The experimental results suggest that the leading-order term (first order of activity) is accurate enough to describe the diffusivities of benzocaine and ethanol in the poly(ethylene-co-vinylacetate) and polyurethane membranes. The linear dependence of permeant diffusivity on swelling-agent activity was further used to analyze the drug diffusion in a membrane subject to a swelling gradient. With the knowledge of the dependence of benzocaine and ethanol diffusivities on ethanol activity, the activity profile of ethanol across the membrane can be calculated, and the effective diffusivity of benzocaine can then be predicted. Experiments carried out to determine the variation in the effective benzocaine diffusivity corresponding to different swelling gradients agreed well with the calculated results.