Gonadotropin-regulated testicular helicase (GRTH/DDX25): a master post-transcriptional regulator of spermatogenesis.
Gonadotropin-regulated testicular helicase (GRTH/DDX25): a master post-transcriptional regulator of spermatogenesis.
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促性腺激素调节的睾丸解旋酶（GRTH/DDX25）：精子发生的主要转录后调节因子。
DOI：
10.1007/978-1-4419-8002-1_6
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发表时间：
2011
影响因子：
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通讯作者：
Tsai-Morris,Chon-Hwa
中科院分区：
文献类型：
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作者：
Dufau,MariaL;Sato,Hisashi;Gutti,Ravi;Tsai-Morris,Chon-Hwa
促性腺激素调节的睾丸RNA解旋酶(Grth/DDX25)是一种多功能蛋白质，在精子发生过程中起着至关重要的作用。缺乏Grth的雄性小鼠是不育的，因为精子细胞无法伸长而导致精子不足。GRTH是一种转运蛋白，作为mRNP颗粒的组成部分，在精子发生过程中参与基因特异性的mRNA输出(几个生精基因及其自身的信息)从核到细胞质位置(即类染色体-mRNA的存储/处理和多核糖体/翻译)。GRth是维持圆形精子细胞中类染色体的结构和功能所必需的。在多聚核糖体中，Grth调控编码生精因子的mRNAs的翻译。此外，GRTH还可防止生殖细胞凋亡。在5.8%的无精子症不育患者中，Grth/DDX25基因错义突变与磷酸化Grth胞浆物种缺失相关，表明Grth是精子发生的转录后调节因子
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a multifunctional protein that is essential for the completion of spermatogenesis. Male mice lacking GRTH are sterile due to the lack of sperm caused by failure of spermatids to elongate. GRTH is a transport protein and as a component of mRNP particles is involved in gene-specific mRNA export (several spermatogenic genes and also its own message) from nuclear to cytoplasmic sites (i.e., chromatoid bodies–mRNA storage/processing and polyribosomes/translation) during spermatogenesis. GRTH is necessary to maintain the structure and function of the chromatoid body in round spermatids. In polyribosomes, GRTH regulates the translation of mRNAs encoding spermatogenic factors. In addition, GRTH prevents germ cell apoptosis. A missense mutation of the GRTH/DDX25 gene associated with the absence of phosphorylated GRTH cytoplasmic species in 5.8% of infertile patients with azoospermia indicates the relevance of GRTH as a post-transcriptional regulator of spermatogenesis