Investigation of frontal cortex, motor cortex and systemic haemodynamic changes during anagram solving
Investigation of frontal cortex, motor cortex and systemic haemodynamic changes during anagram solving
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DOI：
10.1007/978-0-387-74911-2_3
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发表时间：
2008-01-01
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影响因子：
--
通讯作者：
Elwell, Clare E.
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文献类型：
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作者：
Tachtsidis, Ilias;Leung, Terence S.;Elwell, Clare E.
我们之前已经报道了在字谜解决任务中，用近红外光谱(NIRS)测量到的额叶皮质(FC)上氧-(Delta[HBO(2)])、脱氧-(Delta[HHB])和总血红蛋白(Delta[HBT]=Delta[HBO(2)]+Delta[HHB])浓度的变化。这些变化与平均血压(MBP)和心率(HR)的显著增加有关。这项研究的目的是调查先前在字谜解决任务中记录的MBP的变化是否会导致激光多普勒测量的头皮血流量(流量)的相关变化，以及在大脑的控制区(运动皮质：MC)的NIRS血流动力学测量中是否观察到任何变化。在4字母字谜任务中，额叶和运动皮质的Delta[HBO(2)]、Delta[HHb]和Delta[Hbt]均有显著变化(n=11，FC p<；0.01，MC p<；0.01)。伴随这些变化的是MBP(n=11，p<；0.01)和头皮流量(n=9，p=0.01)的显著变化。在7字母字谜任务中，Delta[HBo(2)]和Delta[Hbt](n=11，Fc p<；0.01，MC p<；0.01)发生了显著变化，同时伴随着MBP(n=11，p=0.05)和通量(n=9，p=0.05)的显著变化。在这项研究中，MBP和通量中与任务相关的变化似乎有助于大脑皮层激活和控制区域的近红外信号的变化。
We have previously reported changes in the concentrations of oxy-(Delta[HbO(2)]) deoxy- (Delta[HHb]) and total haemoglobin (Delta[HbT] = Delta[HbO(2)] + Delta[HHb]) measured using near infrared spectroscopy (NIRS) over the frontal cortex (FC) during an anagram solving task. These changes were associated with a significant increase in both mean blood pressure (MBP) and heart rate (HR). The aim of this study was to investigate whether the changes in MBP previously recorded during an anagram solving task produces associated changes in scalp blood flow (flux) measured by laser Doppler and whether any changes are seen in NIRS haemodynamic measurements over a control region of the brain (motor cortex: MC). During the 4-Letter anagram task significant changes were observed in the Delta[HbO(2)], Delta[HHb] and Delta[HbT] in both the frontal and motor cortex (n = 11, FC p < 0.01, MC p < 0.01). These changes were accompanied by significant changes in both MBP (n = 11, p < 0.01) and scalp flux (n = 9, p = 0.01). During the 7-Letter anagram task significant changes were observed in the Delta[HbO(2)] and Delta[HbT] (n = 11, FC p < 0.01, MC p < 0.01), which were accompanied by significant changes in both MBP (n = 11, p = 0.05) and flux (n = 9, p = 0.05). The task-related changes seen in MBP and flux in this study appear to contribute to the changes in the NIRS signals over both the activated and control regions of the cortex.